What is nodular erythema nodosum?

Symptoms can be red to blue. It is usually flat and without swelling, and in extreme cases, the whole surface of the leg can be drawn and, more rarely, to the toes and arms. Created spots may last up to a few weeks. It may be accompanied by fever. It may seem at first glance that cellulitis or insect bites, thrombophlebitis, and fungal infections of the skin, but not so.
Special cause
The most common causes of infectious diseases are streptococcal pharyngitis, group A, mycobacterium lepra, Yersinia and coccidio mucosis. This disease can be the first manifestation of an inflammatory disease, such as inflammatory bowel disease, sarcoidosis, or spondylolateral arthropathy, which can be caused by the administration of sulfonamides, phenytoin, or oral contraceptives.
Common Symptoms
  • Red, painful or sensitive to hot
  • Large (10-4 cm). Normally, more than 6 points do not appear at a time.
  • The nodes change from pink to red to blue to brown over a period of 10 to 7 days.
  • The nodes usually appear suddenly. There are other symptoms, such as fever, as well as swelling, redness, and tenderness in the ankle and knee with these nodes.
Treating the cause is improved by treatment. Supportive care in severe cases, including rest in the bed and keeping the legs, using analgesics or nonsteroidal anti-inflammatory drugs, using an elastic band or socks suitable for foot protection. Diagnostic measures may include blood tests (for example, anti-streptococcal antibody testing, or screening for red blood cell sedimentation), or chest x-rays to check for sarcoidosis or tuberculosis.
To speed up the disease and relieve pain and discomfort, use a moist compress or immerse yourself in the water. Hot water compressors are usually better for relieving pain or inflammation. It is also advisable to use a cool water compressor to reduce itching.
Causes of illness
  • Autoimmune diseases and diseases like chronic bowel inflammation
  • Problem with blood proteins
  • Eating foods that contain colors or preservatives.
  • Take medications such as birth control pills (especially those with high estrogen levels), sulfonamides, iodides and bromides.
  • Incidence of an infection, such as streptococcal infections (more commonly than others), coccidioidomycosis, histoplasmosis, sarcoidosis, blastomycosis, tuberculosis, and infections caused by Yersinia bacteria.

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  1. Pedro-Pons, Agustín (1968). Patología y Clínica Médicas (in Spanish). 6 (3rd ed.). Barcelona: Salvat. p. 193. ISBN 84-345-1106-1
  2. Schwartz, R. A.; Nervi, S. J. (2007). "Erythema nodosum: A sign of systemic disease". American Family Physician. 75 (5): 695–700.
  3. William D. James; Timothy G. Berger; Dirk M. Elston. Andrews' Diseases of the skin : clinical dermatology (11th ed.). [London]: Saunders/ Elsevier. p. 488.


Arezou Mahdipour

Arezou Mahdipour